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Winston-Salem is a city in the U.S. state of North Carolina. Winston-Salem is the county seat and largest city of Forsyth County and the fourth-largest city in the state. Winston-Salem is the second largest municipality in the Piedmont Triad region and is home to the tallest office buildings in the region, such as 100 North Main Street. It is called the "Twin City" for its dual heritage, or "Camel City", a reference to Camel cigarettes and the city's prominent tobacco industry; some locals use "Winston" in informal speech. Winston-Salem is home to three universities and one college: Wake Forest University, a nationally distinguished private university, Winston-Salem State University, a historically-black university founded in 1892, the University of North Carolina School of the Arts, and Salem College, a four-year liberal arts college for women.